Overview Having gallstones is the most common risk factor for this type of cancer. Up to 90 percent of people with gallbladder cancer also have gallstones and an inflamed gallbladder. Understanding Your Diagnosis Cancer of the gallbladder is often hard to detect, partly because of its interior location. Many people do not have any symptoms in the early stages of the disease. Deciding on Treatment Your treatment plan will depend on your age and health, and the extent of your disease. You may need surgery, chemotherapy, radiation therapy, or a combination of these. Managing Side Effects Your doctor or nurse can explain the possible side effects of your treatment and can help manage these side effects. It's important that you let your doctor or nurse know if you experience any side effects.