Overview Factors that increase the risk for uterine cancer include advancing age, being overweight, having diabetes, and having undergone estrogen replacement therapy. Understanding Your Diagnosis In addition to a pelvic exam and a Pap test, other tests your doctor may order include an endometrial biopsy or a dilation and curettage. These tests will help your doctor rule out other medical conditions. Deciding on Treatment Treatment for uterine cancer is either local or systemic. Local treatments such as surgery or radiation therapy remove, destroy, or control cancer cells in one area. Systemic treatments such as chemotherapy destroy or control cancer cells throughout the body. Managing Side Effects Side effects during cancer treatment may be mild or severe enough to interfere with your daily activities. Some side effects are temporary, but others can linger. Your doctor or cancer nurse can suggest ways to ease any side effects that you experience.