Cabozantinib capsules and tablets
What is this medicine?
CABOZANTINIB (KA boe ZAN ti nib) is a medicine that targets proteins in cancer cells and stops the cancer cell from growing. The capsules are used to treat thyroid cancer; the tablets are used to treat renal cell cancer and hepatocellular cancer.
How should I use this medicine?
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Do not take with food. Do not cut, crush, or chew this medicine. Do not take with grapefruit juice. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
bloody or black, tarry stools
changes in vision
chest pain or chest tightness
confusion, trouble speaking or understanding
feeling faint or lightheaded, falls
jaw pain, especially after dental work
red or dark-brown urine
redness, swelling, or sores on hands or feet
shortness of breath, chest pain, swelling in a leg
spitting up blood or brown material that looks like coffee grounds
sudden numbness or weakness of the face, arm or leg
swelling of the ankles, feet, hands
trouble walking, dizziness, loss of balance or coordination
unusual bruising or bleeding from the eye, gums, or nose
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
loss of appetite
What may interact with this medicine?
This medicine may interact with the following medications:
St. John's Wort
What if I miss a dose?
If you miss a dose, take it as soon as you can. If your next dose is to be taken in less than 12 hours, then do not take the missed dose. Take the next dose at your regular time. Do not take double or extra doses.
Where should I keep my medicine?
Keep out of the reach of children.
Store between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
high blood pressure
skin conditions or sensitivity
an unusual or allergic reaction to cabozantinib, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
What should I watch for while using this medicine?
This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.
If you are going to have surgery or any other procedures, tell your doctor you are taking this medicine.
Do not become pregnant while taking this medicine or for 4 months after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine or for 4 months after the last dose.
This medicine may interfere with the ability to have a child. You should talk with your doctor or health care professional if you are concerned about your fertility.