Headache Headaches vary greatly in terms of pain location, pain intensity, and how frequently they occur. Pulling Ahead of Headaches About 90 percent of all headaches are harmless episodes that can be treated with over-the-counter painkillers, either alone or together with rest, ice packs or relaxation techniques. Get the Right Help for Headaches When seeking treatment for headaches, start with your primary care provider. Increased Intracranial Pressure (ICP) Headache A brain injury or another medical condition can cause growing pressure inside your skull. This dangerous condition is called increased intracranial pressure (ICP) and can lead to an ICP headache. The pressure also can injure your brain or spinal cord.