Raynaud's Phenomenon This disorder affects blood flow to the fingers and less frequently to the ears, toes, nipples, knees, or nose. Exposure to cold and emotional upset are the triggers. Scleroderma Scleroderma is a chronic, degenerative disease that can lead to scarring of the skin, joints, and other internal organs. Systemic Lupus Erythematosus (Lupus) Most people who have lupus are young women. The effects of the disease can range from mild to severe.