Folic Acid for a Healthy Baby Getting enough folic acid can reduce the risk for neural tube defects (NTDs) and may also reduce the risk for other serious birth defects of the brain and spinal cord. First Trimester A healthy first trimester is crucial to the normal development of your baby. You may not be showing much on the outside, but inside, all the major body organs and systems of the fetus are forming. First Trimester Screening Screening during the first trimester is a combination of ultrasound and two blood tests. These tests can help determine the risk of certain birth defects. Headaches in Early Pregnancy Managing headaches is especially tricky in the first trimester when you should avoid medications. First Trimester Fatigue For many women, the extreme tiredness of the first trimester is quite a surprise. And it’s an especially hard transition for those who are normally go-getters with lots of energy.